Effect of Intraoperative Nociception Control Based on Analgesia Nociception Index (ANI) Monitoring on Stress Response During Total Laparoscopic Hysterectomy

  • STATUS
    Recruiting
  • days left to enroll
    48
  • participants needed
    72
  • sponsor
    Yonsei University
Updated on 24 January 2021

Summary

The "Analgesia Nociception Index" (ANI; MetroDoloris Medical Systems, Lille, France), derived from an electrocardiogram (ECG) trace, has been proposed as a noninvasive guide to analgesia. The ANI monitor calculates HR variation with respiration, a response mediated primarily by changes in the parasympathetic nervous system (PNS) stimulation to the sinoatrial node of the heart. The aim of this study is to determine the relation between ANI monitor values and serum catecholamine levels. We will compare the serum catecholamine (norepinephrine, epinephrine) levels of conventional nociception control group and ANI-monitor guided nociception control group at the end of surgery.

Details
Condition Patients Undergoing Total Laparoscopic Hysterectomy
Treatment conventional nociception control, ANI monitor guided nociception control
Clinical Study IdentifierNCT04343638
SponsorYonsei University
Last Modified on24 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 20 yrs and 65 yrs?
Are you female?
Do you have Patients Undergoing Total Laparoscopic Hysterectomy?
Do you have any of these conditions: Do you have Patients Undergoing Total Laparoscopic Hysterectomy??
patients undergoing total laparoscopic hysterectomy under general anesthesia (American society of anesthesiologists classification 1~3)

Exclusion Criteria

endometriosis
AP diameter of uterus > 12cm
cognitive disorder
arrhythmia, pacemaker
chronic opioid use
diseases affecting autoimmune system (immune disease, diabetic neuropathy)
use of medications affecting ANI monitor (antimuscarinics, alpha-agonist, beta blocker)
illiteracy, foreigner
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