Metformin to Treat Corticosteroids-induced Hyperglycemia

  • End date
    Dec 25, 2024
  • participants needed
  • sponsor
    The Baruch Padeh Medical Center, Poriya
Updated on 25 January 2021


Antenatal corticosteroids, particularly, betamethasone is routinely administered to pregnant women at risk for preterm delivery to improve neonatal outcomes.

Although antenatal betamethasone was shown to induce both maternal hyperglycemia and neonatal hypoglycemia, to date, there is insufficient data to establish whether treatment for maternal hyperglycemia, particularly, metformin, will decrease the risk for neonatal hypoglycemia, particularly of preterm neonates.

In the present study the investigators will examine the effect of treatment with metformin on maternal glycemic control and hypoglycemia in preterm neonates following maternal betamethasone treatment.

Condition Pregnancy Preterm, Preterm Pregnancy, Glycemic Control, Corticosteroids Induced Hyperglycemia
Treatment Metformin
Clinical Study IdentifierNCT04332393
SponsorThe Baruch Padeh Medical Center, Poriya
Last Modified on25 January 2021


Yes No Not Sure

Inclusion Criteria

Pregnant women receiving betamethasone from 24 to 36.5 gestational weeks
Before or within 24 hours following the first dose of betamethasone
years old

Exclusion Criteria

Women with pre-gestational and gestational diabetes mellitus (GDM)
Known allergic sensitivity to metformin
Known chronic heart failure
Known chronic renal failure
Refuse to participate
Refuse to perform glucose challenge test/glucose tolerance test later on
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note