Metformin to Treat Corticosteroids-induced Hyperglycemia

  • STATUS
    Recruiting
  • End date
    Dec 25, 2024
  • participants needed
    323
  • sponsor
    The Baruch Padeh Medical Center, Poriya
Updated on 25 January 2021

Summary

Antenatal corticosteroids, particularly, betamethasone is routinely administered to pregnant women at risk for preterm delivery to improve neonatal outcomes.

Although antenatal betamethasone was shown to induce both maternal hyperglycemia and neonatal hypoglycemia, to date, there is insufficient data to establish whether treatment for maternal hyperglycemia, particularly, metformin, will decrease the risk for neonatal hypoglycemia, particularly of preterm neonates.

In the present study the investigators will examine the effect of treatment with metformin on maternal glycemic control and hypoglycemia in preterm neonates following maternal betamethasone treatment.

Details
Condition Pregnancy Preterm, Preterm Pregnancy, Glycemic Control, Corticosteroids Induced Hyperglycemia
Treatment Metformin
Clinical Study IdentifierNCT04332393
SponsorThe Baruch Padeh Medical Center, Poriya
Last Modified on25 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Pregnant women receiving betamethasone from 24 to 36.5 gestational weeks
Before or within 24 hours following the first dose of betamethasone
years old

Exclusion Criteria

Women with pre-gestational and gestational diabetes mellitus (GDM)
Known allergic sensitivity to metformin
Known chronic heart failure
Known chronic renal failure
Refuse to participate
Refuse to perform glucose challenge test/glucose tolerance test later on
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