Role of Delay and Antibiotics on Perforation Rate While Waiting Appendectomy

  • STATUS
    Recruiting
  • End date
    Jan 4, 2023
  • participants needed
    1800
  • sponsor
    Helsinki University Central Hospital
Updated on 4 September 2021
antibiotic therapy
antibiotics
metronidazole
MRI
appendectomy

Summary

This study evaluates the effects of preoperative delay and antibiotics on perforation rate of appendix while waiting surgery for acute appendicitis. Patients with diagnosed acute appendicitis are randomized into two urgency groups: surgery within 8 hours or surgery within 24 hours. In addition, patients are randomized to either receive antibiotics while waiting or waiting without antibiotics.

Details
Condition Gastroenteritis, Appendicitis, Acute Appendicitis, Intraabdominal Infections
Treatment No antibiotics, Antibiotics, cefuroxime and metronidazole, urgent schedule, less urgent schedule
Clinical Study IdentifierNCT04378868
SponsorHelsinki University Central Hospital
Last Modified on4 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Acute appendicitis where surgery is planned. Diagnosis of appendicitis should be verified either by clinical diagnosis with Adult Appendicitis Score >=16 or by diagnostic imaging (CT-scan, MRI or ultrasound) showing appendicitis. All patients with symptoms at least 3 days should undergo diagnostic imaging before inclusion

Exclusion Criteria

Complicated appendicitis according to diagnostic imaging. The following findings indicate complicated appendicitis: extraluminal air or extraluminal fecalith; fluid collection, abscess or phlegmon next to appendix; non-enhancement appendiceal wall on contrast enhanced CT-scan
Plasma C-reactive protein >=100
Fever measured on emergency department over 38.5 degrees Celcius
Clinical generalized peritonitis or other reason that indicate immediate surgery
Pregnancy, pregnancy test is taken from all fertile aged women before randomization
Allergy to study antibiotics, or anaphylactic reaction after betalactam antibiotic or other contraindication for metronidazole or ongoing antibiotic treatment or patient is carrier of resistant bacteria. (This exclusion criteria are applicable only on randomization into antibiotic treatment arms)
Missing written informed consent
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