Ocular Sequelae of Patients Hospitalized for Respiratory Failure During the COVID-19 Epidemic

  • STATUS
    Recruiting
  • days left to enroll
    18
  • participants needed
    100
  • sponsor
    Fondation Ophtalmologique Adolphe de Rothschild
Updated on 26 January 2021
respiratory failure
PCR test
uveitis
coronavirus infection
hypercytokinemia

Summary

Ophthalmologic damages secondary to COVID-19 coronavirus infection are little described. The ocular involvement is probably multiple, ranging from pathologies of the anterior segment such as conjunctivitis and anterior uveitis to disorders that threaten vision such as retinitis or optic neuropathy. On the other hand, in addition to this impairment, when patients are hospitalized for acute respiratory failure, complications related to possible resuscitation, medication prescriptions, positioning and oxygenation.

COVID-19 itself, has several components:

  • An apoptotic action of the viral attack which will generate cellular destruction, whether pulmonary, cardiac or renal or maybe ocular
  • A secondary autoimmune action with the development of major vascular inflammation, possibly reaching the retinal, choroidal, and optic nerve vessels. A secondary "hyper" inflammatory syndrome with flashing hypercytokinemia and multi-organ decompensation is described in 3,7% to 4 ,3% of severe cases.
  • A thromboembolic action

Description

Upon discharge from hospital for COVID-19 infection (or during a telephone call for patients already discharged at the start of the study), patients will be informed of the study. An ophthalmology appointment will be given to them between 4 and 6 months after their discharge.

During the ophthalmology appointment, the patient's clinical data will be collected during an interview (medical and treatment history, blood group). The patient will benefit from a full ophthalmological examination.

Details
Condition EYE DISORDER, Eye Disorders/Infections, Dry Eye Disease, Eye Disorders/Infections (Pediatric), Eye Disease, COVID19, ocular disease, ophthalmological disorder
Treatment Ophthalmologic exam
Clinical Study IdentifierNCT04387292
SponsorFondation Ophtalmologique Adolphe de Rothschild
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have any of these conditions: Eye Disease or Dry Eye Disease or COVID19 or EYE DISORDER or Eye Disorders/Infections (Pediatric) or Eye Disorders/Infections?
Do you have any of these conditions: Dry Eye Disease or Eye Disorders/Infections (Pediatric) or COVID19 or ophthalmological disorder or Eye Disease or EYE DISORDER or ocular disease or Ey...?
Patients having been hospitalized for a confirmed COVID-19 infection (CT-scanner or PCR- Polymerase chain reaction)

Exclusion Criteria

Pregnant or breastfeeding woman
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