Last updated on May 2020

Neuroimmune Dysfunction in Alcohol Use Disorder


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Cognitive Dysfunction | pathological process | Drinking Behavior | Drug use | Neurocognitive Disorders | Inflammation | Antibiotic | Alcohol Dependence | Alcohol use | Chemically-Induced Disorders | Minocycline | Disease | Mental illness | Alcohol Use Disorder | Alcohol abuse | Substance Abuse | Alcohol-Related Disorders | Psychosis | Anti-Infective Agents | Cognitive Disorder | Drug abuse
  • Age: Between 25 - 55 Years
  • Gender: Male or Female

AUD Group Inclusion Criteria:

  • Meet DSM-5 diagnostic criteria for an AUD
  • Begin drinking alcohol prior to the age of 18
  • In the 30-day period before enrollment, consume 14 and 7 standard drinks per week for men and women, respectively, AND
  • In the 30-day period before enrollment, engage in heavy drinking 1 times per week (5 or more drinks for men, 4 or more drinks for women) and 5 times per month

AUD Group Exclusion Criteria:

  • Currently in treatment for AUD, a history of treatment within the 30 days before enrollment, or currently seeking immediate treatment
  • Current (last 12 months) DSM-5 diagnosis of substance use disorder for any psychoactive substances other than alcohol and nicotine
  • Recreational marijuana use > 3 times weekly during 30 days before enrollment
  • Lifetime DSM-5 diagnosis of schizophrenia spectrum and other psychotic disorders and bipolar and related disorders
  • Positive urine toxicology screen for illicit substances (excluding marijuana)
  • Serious alcohol withdrawal symptoms as indicated by a score 10 on the Clinical Institute Withdrawal Assessment for Alcohol-Revised
  • If female: pregnancy, nursing, or refusal to use reliable method of birth control; if using hormonal contraceptives, refusal to use secondary birth control method
  • A medical condition that may interfere with safe study participation (e.g., unstable cardiac, renal, or liver disease, uncontrolled hypertension or diabetes)
  • alanine aminotransferase (ALT), aspartate aminotransferase (AST), or -glutamyl transferase (GGT) 3 times upper normal limit
  • Attempted suicide in the past 3 years and/or serious suicidal intention or plan within the past year
  • Currently on prescription medication that contraindicates use of minocycline
  • Previously known hypersensitivity to tetracyclines
  • Current or recent (within one month) treatment with tetracycline, tetracycline derivative, or any other antibiotic
  • Claustrophobia or physical issues preventing MRI scan
  • Presence of a metal device in the body (e.g., pacemaker, infusion pump, aneurysm clip, metal prosthesis or plate)
  • Current or recent (within 3 months) participation in a clinical trial involving medication administration
  • History of traumatic brain injury
  • Having below a 6th grade reading level
  • Any other circumstances that, in the opinion of the investigators, compromises participant safety

Healthy Control Group Inclusion Criteria:

  • Do not meet DSM-5 diagnostic criteria for an AUD
  • Begin drinking alcohol to the age of 18
  • In the 30-day period before enrollment, consume 14 and 7 standard drinks per week for men and women, respectively
  • Engage in infrequent heavy drinking during the past 6 months ( 2 heavy drinking events in past 6 months)

Healthy Control Group Exclusion Criteria:

  • Lifetime DSM-5 diagnosis of substance use disorder for any psychoactive substances other than nicotine
  • Lifetime DSM-5 diagnosis of schizophrenia spectrum and other psychotic disorders, bipolar and related disorders, depressive disorders, anxiety disorders (panic disorder, agoraphobia, social anxiety, and generalized anxiety), obsessive-compulsive and related disorders, trauma- and stressor-related disorders, feeding and eating disorders (binge eating, anorexia, and bulimia), conduct disorders, and gambling disorder
  • Recreational marijuana use > 3 times weekly during 30 days before enrollment
  • Positive urine toxicology screen for illicit substances (excluding marijuana)
  • If female: pregnancy, nursing, or refusal to use reliable method of birth control; if using hormonal contraceptives, refusal to use secondary birth control method
  • A medical condition that may interfere with safe study participation (e.g., unstable cardiac, renal, or liver disease, uncontrolled hypertension or diabetes)
  • AST, ALT, or GGT 3 times upper normal limit
  • Attempted suicide in the past 3 years and/or serious suicidal intention or plan within the past year
  • Currently on prescription medication that contraindicates use of minocycline
  • Previously known hypersensitivity to tetracyclines
  • Current or recent (within one month) treatment with tetracycline, tetracycline derivative, or any other antibiotic
  • Claustrophobia or physical issues preventing MRI scan
  • Presence of a metal device in the body (e.g., pacemaker, infusion pump, aneurysm clip, metal prosthesis or plate)
  • Current or recent (within 3 months) participation in a clinical trial involving medication administration
  • History of traumatic brain injury
  • Having below a 6th grade reading level
  • Any other circumstances that, in the opinion of the investigators, compromises participant safety

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Volunteer Sign-up

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.