Study of Metabolic Changes in the Transformation Malignant Precancerous Skin Lesions (MITOSKIN)

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  • sponsor
    University Hospital, Bordeaux
Updated on 24 May 2022
skin lesion
squamous cell carcinoma
skin lesions
actinic keratosis


Skin carcinomas are the most frequent cancers in the world, including basal cell carcinomas and cutaneous squamous cell carcinoma (cSCCs), with more than 60.000 new annual cases in France. Their incidence increases mainly due to ultraviolet (UV) exposure and population ageing. Then from 1994 to 2006, the incidence of cSCC has increased by 300%. CSCCs typically manifests as a spectrum from a precursor actinic keratosis (AK) - possible spontaneous regression at this stage- to in situ cSCC invasive cSCC and finally metastatic cSCC.


Although growing evidence indicates that bioenergetic metabolism plays an important role in the progression of tumorigenesis, little information is available on the contribution of reprogramming of energy metabolism in cancer initiation and how it influences further the bioenergetic behavior of tumors.

By applying a quantitative proteomic approach, the consortium has recently found that specific metabolic modifications precede cSCC.

This study will investigate the role of energy metabolism in malignant transformation of premalignant skin lesions into cSCC, and in cSCC progression, with correlation with clinical characteristics and metastatic outcomes. Using several cutting-edge technologies in human samples, the team will evaluate whether targeting energy metabolism has the potential to be used as curative treatments for cSCC and whether pre-determined metabolic alterations could be exploited as new preventive strategies. These modifications in energy metabolism could be used as prognostic and diagnostic biomarkers.

Condition Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinomas
Treatment biopsy
Clinical Study IdentifierNCT04389112
SponsorUniversity Hospital, Bordeaux
Last Modified on24 May 2022


Yes No Not Sure

Inclusion Criteria

Every patient with suspected lesion
in situ cSCC
infiltrative cSSC
cSCC with recurrent disease
cSCC with cutaneous metastases
Patients 18 years of age or older
Patients with suspected AK or BCC lesions (in situ, infiltrating or metastatic)
Patient able to sign a consent form
Patient affiliated with a Social Security system

Exclusion Criteria

Prior systemic treatment such as checkpoint inhibitors or chemotherapy
Patients with cSCC or AK localized on visible zone of the face or folds
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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