Magnesium Replacement and Hyperglycemia After Kidney Transplantation

  • STATUS
    Recruiting
  • End date
    Aug 31, 2022
  • participants needed
    40
  • sponsor
    Oslo University Hospital
Updated on 6 October 2021
diabetes
calcineurin inhibitor
kidney transplant

Summary

The insulin receptor is dependent on magnesium and hypomagnesemia is associated with increased insulin resistance and decreased insulin secretion and action. Recent data suggest that hypomagnesemia may play a role in development of type 2 diabetes. Kidney transplantation patients have low plasma magnesium levels, partly due to treatment with calcineurin inhibitors. However, the role of magnesium in the development of post-transplant diabetes mellitus (PTDM) is unclear.

The present study addresses, whether hypomagnesemia is feasible to reverse by oral administration of magnesium.

The investigators wish to investigate whether oral magnesium supplementation is sufficient to increase magnesium levels in kidney transplant recipients, and if supplementation improves glycemic parameters as measured by an oral glucose tolerance test (OGTT).

Details
Condition Organ Transplantation, Renal transplant, Hypomagnesemia, Organ Transplant - Pediatric, Organ Transplant, Kidney Transplantation, kidney transplant, renal transplantation, kidney transplants
Treatment Placebo, Mablet 360 mg
Clinical Study IdentifierNCT04382157
SponsorOslo University Hospital
Last Modified on6 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Kidney transplant recipients more than one year after transplantation
Hypomagnesemia (< 0.7 mmol/L)
Age 18 years and able to give written informed consent

Exclusion Criteria

Current treatment with magnesium containing medication or supplements
Current medical treatment for diabetes
Conditions impairing magnesium absorption from the gastrointestinal tract (e.g. short bowel syndrome, chronic pancreatitis)
Subjects with primary non-graft function and subjects with need of dialysis therapy >2 months or graftectomy at any time point after transplantation
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