Thalidomide Cyclophosphamide Oral Idarubicin and Dexamethasone (T-CID) in Patients With Multiple Myeloma

  • STATUS
    Recruiting
  • participants needed
    80
  • sponsor
    University Hospital, Bonn
Updated on 7 November 2020
cancer
cyclophosphamide
maintenance therapy
cell transplantation
leukemia
induction therapy
dexamethasone
progressive disease
thalidomide
plasma cell leukemia
high dose chemotherapy
refractory multiple myeloma

Summary

Background: In some studies, thalidomide in combination with chemotherapy has been shown to be effective in patients with relapsed or refractory multiple myeloma (MM). In this study, the researchers have chosen a regimen which can be administered on an outpatient basis. Induction therapy: To evaluate the efficacy and toxicity of thalidomide, cyclophosphamide, oral idarubicin and dexamethasone (T-CID) in patients with relapsed or refractory multiple myeloma. Maintenance therapy: Randomized trial to compare efficacy and toxicity of thalidomide and thalidomide plus oral idarubicin as maintenance therapy in patients with at least stable disease after T-CID.

Description

Background: In some studies, thalidomide in combination with chemotherapy has been shown to be effective in patients with relapsed or refractory multiple myeloma (MM). In this study, the researchers have chosen a regimen which can be administered on an outpatient basis. After 3-8 cycles of T-CID patients with at least stable disease will be randomized to receive thalidomide or thalidomide plus oral idarubicin as maintenance therapy for at least one year or until progression.

Details
Condition Multiple Myeloma
Treatment Idarubicin, thalidomide
Clinical Study IdentifierNCT00124813
SponsorUniversity Hospital, Bonn
Last Modified on7 November 2020

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