Measurement of Renal Functional Reserve Change In Patients With SRC Before and After Laparoscopic Deroofing

  • STATUS
    Recruiting
  • End date
    Dec 31, 2021
  • participants needed
    200
  • sponsor
    ou tongwen
Updated on 24 January 2021

Summary

Renal functional reserve may be improved in patients with simple renal cysts after laparoscopic deroofing.

Description

Simple renal cysts (SRC) are the most frequent type of cystic renal disease. The prevalence rate of SRCs is about 10% and increases with age. Hypertension and decreased renal functions have been reported to occur more commonly among these patients with SRC and there are no clear guidelines for managing asymptomatic SRCs.Renal functional reserve (RFR) describes the capacity of the intact nephron mass to increase glomerular filtration rate(GFR) from baseline in response to stimuli (e.g., protein load).The investigators hypothesized that RFR may be improved in some patients with simple renal cysts after laparoscopic deroofing despite identical resting glomerular filtration rate (rGFR).The aim of this study is to examine whether there is improvement of RFR in patients with simple renal cysts after laparoscopic deroofing.

Details
Condition Simple Renal Cyst
Treatment Laparoscopic deroofing, 100 g of amino acids supplementation
Clinical Study IdentifierNCT03259594
Sponsorou tongwen
Last Modified on24 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 18 yrs and 90 yrs?
Gender: Male or Female
Do you have Simple Renal Cyst?
Do you have any of these conditions: Do you have Simple Renal Cyst??
Age 18
Estimated GFR >30 mL/min/1.73m2
Subjects who signed informed consent forms

Exclusion Criteria

Allergy to iothalamate, shellfish or iodine
Use of metformin or amiodarone
Inability to maintain a stable regimen of medications which affect GFR for > one week prior to participation (e.g. non-steroidal anti-inflammatory drugs, angiotensin converting enzyme inhibitors, angiotensin receptor blockers)
Use of medications which directly affect elimination of creatinine (e.g. cimetidine and trimethoprim)
Acute exacerbation of asthma or chronic obstructive pulmonary disease within 3 months requiring hospitalization or oral steroid therapy
Inadequate intravenous access
Severe anemia (Hct <21%)
Acute kidney injury (rise in creatinine to 1.5 times the previous baseline or by 0.3 mg/dL on most recent labs prior to enrollment)
History of contrast-induced nephropathy
Hyperthyroidism
Pheochromocytoma
Sickle cell disease
Urinary retention or incontinence
Status post organ transplant
Pregnancy or active breast feeding
Cognitive impairment with inability to give consent
Institutionalized status
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