Last updated on March 2020

BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Chagas Disease | Heart Disease | Trypanosomiasis
  • Age: Between 18 - 75 Years
  • Gender: Male or Female
  • Other:
    Consenting patients (between 18 and 75 years of age) with serological evidence of
    Chagas infection (any combination of 2 positive tests) and that have one or more of
    the following:
    Abnormal electrocardiogram with at least two components (complete RBBB or LBBB; left
    anterior or posterior fascicular block; ventricular premature beat; first degree
    atrioventricular [AV] block; Mobitz type I AV block; sinus bradycardia; primary ST-T
    changes; abnormal Q waves; low voltage QRS; or atrial fibrillation);
    Abnormal ECG (Mobitz type II, advanced or third degree AV block);
    Increased cardiothoracic ratio (> 0.50);
    Complex ventricular arrythmias on 24 hour ambulatory ECG monitoring;
    Evidence of regional wall motion abnormality or reduced global left ventricular
    ystolic function or increased left ventricular and diastolic diameter on 2D-Echo.

You may not be eligible for this study if the following are true:

  • Patients will be excluded if having:
    NYHA heart failure class IV or decompensated heart failure
    Evidence of concomitant coronary artery disease (CAD) or other etiology of dilated
    Previous treatment with antitrypanosomal agents or an accepted indication for
    antiparasitic therapy
    Inability to comply with follow-up visits
    History of severe alcohol abuse within 2 years
    Known chronic renal or hepatic insufficiency or hepatic insufficiency
    Pregnancy or breast feeding
    Megaesophagus with swallowing impairment
    Other severe disease significantly curtailing life expectancy

Recruitment Status: Closed

Brief Description Eligibility Contact Research Team

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