Memantine for Epileptic Encephalopathy

  • End date
    Feb 28, 2022
  • participants needed
  • sponsor
    Kenneth Myers, MD
Updated on 25 January 2021


This study will evaluate the potential benefit of memantine hydrochloride as treatment for children with epileptic encephalopathy using a double-blind placebo-controlled cross-over design.


Memantine, a drug approved for Alzheimer's dementia, exerts its therapeutic effect through its action as a low to moderate affinity non-competitive (open channel) N-methyl-D-aspartate receptor (NMDA-R) antagonist, which binds preferentially to the NMDA receptor-operated cation channels. It blocks the effects of persistently elevated levels of glutamate that may lead to neuronal dysfunction. Memantine may also have anti-inflammatory effects. Memantine has been used off-label in children and adolescents with autism spectrum disorder, to improve the cognitive impairment.

Epileptic encephalopathy, as well as other forms of epilepsy, may occur as a result of multiple etiologies, including genetic and inflammatory pathologies. Ion channels were long considered to be implicated in genetic epilepsy. Indeed one of the many possible causes of epilepsy is NMDA receptor dysfunction.

In the present study, the investigators plan to investigate the potential benefit of memantine as a treatment for epileptic encephalopathy. A double-blind placebo-controlled cross-over design will be used, with participants receiving 6 weeks of memantine and 6 weeks of placebo, with a 2-week washout period in between.

Condition Epileptic Encephalopathy, Childhood-Onset, Epileptic Encephalopathy, Childhood-Onset
Treatment Memantine Hydrochloride 10 mg
Clinical Study IdentifierNCT03779672
SponsorKenneth Myers, MD
Last Modified on25 January 2021


Yes No Not Sure

Inclusion Criteria

Is your age between 6 yrs and 18 yrs?
Gender: Male or Female
Do you have Epileptic Encephalopathy, Childhood-Onset?
Do you have any of these conditions: Do you have Epileptic Encephalopathy, Childhood-Onset??
Written informed consent obtained
Age 6-18 years (Weight 20 kg)
Clinical diagnosis of epileptic encephalopathy
Subject with epilepsy and developmental impairment
Epileptic activity itself contributes to severe cognitive and behavioural impairments
Patients will typically have already have trialed at least two standard therapies
Females of childbearing age
Negative urinary pregnancy test at screening
Agree to use effective contraception for the duration of the study

Exclusion Criteria

Inability of a parent or legal guardian to give informed consent for any reason
Known hypersensitivity to memantine hydrochloride
Taking concomitant Amantadine, Ketamine or Dextromethorphan, Cimetidine, Ranitidine, Procainamide, Quinidine, Quinine, Hydrochlorothiazide, Anticholinergics, L-dopa, Anticoagulant
Any degree of renal impairment
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