A Phase 1 Study of SEA-TGT (SGN-TGT) in Subjects With Advanced Malignancies

  • days left to enroll
  • participants needed
  • sponsor
    Seagen Inc.
Updated on 27 October 2022
stem cell transplantation
hodgkin's disease
systemic therapy
measurable disease
combination chemotherapy
progressive disease
positron emission tomography
cancer chemotherapy
diffuse large b-cell lymphoma
b-cell lymphoma
solid tumour
solid tumor
targeted therapy
t-cell lymphoma
peripheral t-cell lymphoma
brentuximab vedotin
large b-cell lymphoma
salvage therapy
stage iv non-small cell lung cancer
pd-1 inhibitor


This trial will look at a drug called SEA-TGT (also known as SGN-TGT) to find out whether it is safe for patients with solid tumors and lymphomas. It will study SEA-TGT to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study whether SEA-TGT works to treat solid tumors and lymphomas.

The study will have three parts. Part A of the study will find out how much SEA-TGT should be given to patients. Part B will use the dose found in Part A to find out how safe SEA-TGT is and if it works to treat solid tumors and lymphomas. Part C will study how well SEA-TGT with sasanlimab works to treat solid tumors.

Condition Non-small Cell Lung Cancer, Gastric Carcinoma, Gastroesophageal Junction Carcinoma, Classical Hodgkin Lymphoma, Diffuse Large B-cell Lymphoma, Peripheral T-cell Lymphoma, Cutaneous Melanoma, Head and Neck Squamous Cell Carcinoma, Bladder Cancer, Ovarian Cancer, Triple Negative Breast Cancer, Cervical Cancer
Treatment Pembrolizumab, SGN-TGT, PD-(L)1 inhibitor, SEA-TGT, Sasanlimab
Clinical Study IdentifierNCT04254107
SponsorSeagen Inc.
Last Modified on27 October 2022


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