A Phase 1 Study of SEA-TGT (SGN-TGT) in Subjects With Advanced Malignancies
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- STATUS
- Recruiting
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- days left to enroll
- 54
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- participants needed
- 397
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- sponsor
- Seagen Inc.
Summary
This trial will look at a drug called SEA-TGT (also known as SGN-TGT) to find out whether it is safe for patients with solid tumors and lymphomas. It will study SEA-TGT to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study whether SEA-TGT works to treat solid tumors and lymphomas.
The study will have three parts. Part A of the study will find out how much SEA-TGT should be given to patients. Part B will use the dose found in Part A to find out how safe SEA-TGT is and if it works to treat solid tumors and lymphomas. Part C will study how well SEA-TGT with sasanlimab works to treat solid tumors.
Details
| Condition | Non-small Cell Lung Cancer, Gastric Carcinoma, Gastroesophageal Junction Carcinoma, Classical Hodgkin Lymphoma, Diffuse Large B-cell Lymphoma, Peripheral T-cell Lymphoma, Cutaneous Melanoma, Head and Neck Squamous Cell Carcinoma, Bladder Cancer, Ovarian Cancer, Triple Negative Breast Cancer, Cervical Cancer |
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| Treatment | Pembrolizumab, SGN-TGT, PD-(L)1 inhibitor, SEA-TGT, Sasanlimab |
| Clinical Study Identifier | NCT04254107 |
| Sponsor | Seagen Inc. |
| Last Modified on | 27 October 2022 |
Eligibility
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