Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

  • End date
    Dec 31, 2025
  • participants needed
  • sponsor
    Washington University School of Medicine
Updated on 24 April 2022
residual disease
cancer diagnosis
clinical decision-making
solid tumour
solid tumor
precision medicine
Accepts healthy volunteers


Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes. This project is translational and has the potential to lead to future translational research opportunities, including interventional trials in which therapeutic escalation is offered at the early circulating tumor DNA (ctDNA) molecular residual disease (MRD) detection timepoint. Ultimately, the integration of ctDNA into the clinical workflow has the potential to enhance cancer diagnosis, treatment, surveillance, and prognosis, and guide clinical decision-making in this era of personalized precision medicine.

Condition Healthy Volunteer, Prostate Cancer, Head and Neck Cancer, Esophageal Cancer, Genitourinary Cancer, Sarcoma, Breast Cancer, Colon Cancer, Gastrointestinal Cancer, Solid Tumor Cancer, Lung Cancer, Skin Cancer, Melanoma
Clinical Study IdentifierNCT04354064
SponsorWashington University School of Medicine
Last Modified on24 April 2022


Yes No Not Sure

Inclusion Criteria

Eligible healthy donors will be at least 18 years of age

Exclusion Criteria

Healthy donors younger than 18 years of age
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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