Study of Samarium Sm-153 Lexidronam Combined With Docetaxel for Patients With Prostate Cancer

  • STATUS
    Recruiting
  • participants needed
    69
  • sponsor
    Cytogen Corporation
Updated on 7 November 2020
cancer
androgens
endocrine therapy
testosterone
metastasis
neutrophil count
hormone therapy
docetaxel
antiandrogen therapy
bone scan
antiandrogens
metastatic prostate cancer
bone metastases
adenocarcinoma
bisphosphonate
adenocarcinoma of prostate
prostate cancer metastatic
diphosphonates

Summary

The purpose of this study is to investigate the safety, tolerability and anti-tumor effects of treatment with samarium Sm-153 lexidronam in combination with docetaxel in patients with castrate metastatic prostate cancer.

Description

The principal objective of this trial is to evaluate the safety, feasibility, and anti-tumor effects of a novel bone-targeted regimen consisting of Samarium Sm-153 lexidronam combined with docetaxel and prednisone. This present study design permits evaluation of the clinical activity of combining two distinct agents that have shown benefit for the treatment of patients with advanced androgen-independent prostate cancer and bone metastases. It enables assessment of potential synergistic interactions between a cytotoxic chemotherapy agent and a bone-targeting radioisotope agent in the setting of a bone-targeted therapy.

Details
Condition Malignant neoplasm of prostate
Treatment Samarium Sm-153 lexidronam + Docetaxel
Clinical Study IdentifierNCT00121095
SponsorCytogen Corporation
Last Modified on7 November 2020

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