Role of the Environment and Endocrine Disruptors in Child Cryptorchidism

  • STATUS
    Recruiting
  • End date
    Oct 24, 2021
  • participants needed
    1200
  • sponsor
    University Hospital, Montpellier
Updated on 24 January 2021

Summary

Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer. As a major public health objective, it's the subject of numerous recommendations. Its frequency is increasing in some countries faster than a single genetic cause could not explain it. It may occurs in a geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular migration. The aim of the study is to find out if some environmental exposition may be associated with cryptorchidism.

Description

Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer. As a major public health objective, it's the subject of numerous recommendations. Its frequency is increasing in some countries faster than a single genetic cause could not explain it. It may occurs in a geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular migration. The aim of the study is to find out if some environmental exposition may be associated with cryptorchidism.

Details
Condition Undescended testicle, cryptorchidism, undescended testes
Treatment Measure of the exposure of parent of male with /without cryptorchidism to endocrine disruptors
Clinical Study IdentifierNCT04342026
SponsorUniversity Hospital, Montpellier
Last Modified on24 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Parents of male children from the neonatal period to 18 years of age (during surgery) with cryptorchidism

Exclusion Criteria

Parents of children without endocrine disease. (adrenal, hypothalamic-pituitary, phosphocalcic, thyroid, diabetes, etc.)
Parents of children without an associated genital or urinary defect (hypospadias, micropenis, renal and bladder abnormalities)
Testicular Ectopia (testis outside of normal migration path)
Anorchidism and evanescent testicles, united or bilateral
Abnormalities of the abdominal wall (laparoschisis, omphalocele, Prune Belly)
Cryptorchidism integrating in the context of a polymalformative syndrome, including neurological
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