Bariatric Surgery Effect Nonalcoholic Fatty Liver Disease

  • STATUS
    Recruiting
  • End date
    Jun 21, 2023
  • participants needed
    142
  • sponsor
    Beijing Friendship Hospital
Updated on 5 March 2022
diabetes
insulin
body mass index
type 2 diabetes mellitus
insulin resistance
MRI
liver disease
fatty liver
hemoglobin a1c
glycosylated hemoglobin
steatosis
bariatric surgery
dyslipidemia

Summary

This is a prospective cohort study, which subjects were obese patients requiring bariatric surgery.

The bariatric procedures include laparoscopic sleeve gastrectomy (LSG), laparoscopic Roux-en-Y gastric bypass (LRYGB), and one anastomosis gastric bypass-mini gastric bypass (OAGB-MGB).

The main observation is the cure rate of NAFLD:percentage of liver fat content <5% of abdominal magnetic resonance imaging(MRI) at 1 year after surgery.

In addition, secondary observations include the excess weight loss (%EWL), total weight loss(%TWL), change of HbA1c, level of insulin resistance, blood lipid level alanine aminotransferase(ALT), liver fat fraction in MRI, alpha-fetoprotein and liver pathology.

Aim to prove that bariatric surgery can effectively cure obese NAFLD.

Details
Condition Complication of Bariatric Procedure, Fatty Liver, Non-Alcoholic Fatty Liver Disease
Treatment LSG, LRYGB, OAGB-MGB
Clinical Study IdentifierNCT04366999
SponsorBeijing Friendship Hospital
Last Modified on5 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients were accepted for surgery if they satisfied the guidelines of the Society of Chinese Gastroenterological Surgeons [body mass index (BMI) 32.5 kg/m2 or 27.5 BMI 32.5 kg/m2 with at least one co-morbidity associated with obesity (type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea), and failure of conservative treatment over 2 years].Especially with type 2 diabetes, the recommended level of surgery can be increased as appropriate 25kg/m2
Imaging or pathological findings suggest liver steatosis: i. Preoperative abdominal ultrasound showed fatty liver; ii. Preoperative abdominal magnetic resonance showed liver fat content 5%; iii. Intraoperative liver pathology suggests the presence of liver steatosis

Exclusion Criteria

any patient who had previously been submitted to any type of bariatric surgery
history of excessive drinking: in the past 12 months, the male equivalent of alcohol consumption more than 30g/d, and the female more than 20g/d
history of taking amiodarone, methotrexate, tamoxifen, glucocorticoids, etc
history of specific diseases: Gene type 3 hepatitis C virus (HCV) infection, hepatolenticular degeneration, autoimmune hepatitis, total parenteral nutrition, lack of beta lipoproteinemia, congenital lipid atrophy, celiac disease which causing fatty liver, etc
previous major gastrointestinal surgery
diagnosed or suspected malignancy
poorly controlled significant medical or psychiatric disorders
disorders such as a medical history of major pathology
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