Tranexamic Acid in Radical Resection and Endoprosthetic Reconstruction

  • STATUS
    Recruiting
  • End date
    Dec 1, 2024
  • participants needed
    90
  • sponsor
    University of Kansas Medical Center
Updated on 4 June 2022
soft tissue sarcoma

Summary

This study intends to determine if any correlation exists between administration of TXA or not to musculoskeletal oncology patients undergoing endoprosthetic reconstruction and blood loss and blood transfusion rates.

Description

Resection of bony and soft tissue tumors with endoprosthetic reconstruction often presents a significant risk of perioperative blood loss requiring transfusion. Tranexamic acid (TXA) is an antifibrinolytic that is commonly used to reduce blood loss in orthopedic procedures, most often arthroplasty. The aim of this study is to determine in a randomized controlled fashion if there is any difference in perioperative blood loss and blood transfusion rates when TXA is used compared to when it is not used in patients undergoing radical resection of bone and soft tissue sarcomas with endoprosthetic reconstruction.

Details
Condition Musculoskeletal Cancer, Sarcoma,Soft Tissue
Treatment Tranexamic Acid (TXA)
Clinical Study IdentifierNCT04347122
SponsorUniversity of Kansas Medical Center
Last Modified on4 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients undergoing wide resection of a malignant bony tumor of the lower extremity with endoprosthetic reconstruction
Patients undergoing a resection of soft tissue sarcoma measuring > 5cm

Exclusion Criteria

Patients undergoing revision endoprosthetic reconstruction
Patients with known coagulopathy
Known history of DVT or embolic disease
Benign tumors
Patients with allergy to TXA
Those refusing blood products
Those concurrently on anti-coagulant therapy
Pregnant and/or nursing women
Vulnerable populations as defined by the KUMC IRB
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