Effect of Treatments in Patients Hospitalized for Severe COVID-19 Pneumonia: a Multicenter Cohort Study

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    400
  • sponsor
    Groupe Hospitalier Pitie-Salpetriere
Updated on 9 April 2021
pneumonia
azithromycin
mechanical ventilation
lopinavir/ritonavir
covid-19
SARS
remdesivir
hydroxychloroquine
assisted breathing
assisted ventilation
baricitinib
oseltamivir
tocilizumab

Summary

Several treatments have been used in during the Covid-19 pandemic of 2020. Using patients' registries from several hospitals in Paris, the investigators retrospectively analyzed associations between specific treatments, including but not limited to vaccines targeted against SARS-CoV-2, hydroxychloroquine, azithromycin, remdesivir, baricitinib, tocilizumab, sarilumab, lopinavir/ritonavir and oseltamivir; and clinical outcomes including, death and mechanical ventilation.

Description

Several treatments have been used in during the Covid-19 pandemic of 2020. Using patients' registries from several hospitals in Paris, the investigators retrospectively analyzed associations between specific treatments, including but not limited to vaccines targeted against SARS-CoV-2, hydroxychloroquine, azithromycin, remdesivir, baricitinib, tocilizumab, sarilumab, lopinavir/ritonavir and oseltamivir; and clinical outcomes including, death and mechanical ventilation.

Other outcomes of interest include: acute kidney injury, encephalopathy, need for intensive care unit transfers.

Details
Condition Pulmonary Disease, Upper respiratory infection, Pneumonia, ADULT RESPIRATORY DISTRESS SYNDROME, Throat and Tonsil Infections, Acute Respiratory Distress Syndrome (ARDS), Pneumonia (Pediatric), Lung Disease, *COVID-19, Covid-19, pneumoniae, pneumonitis, lung inflammation, acute respiratory distress syndrome, ards
Clinical Study IdentifierNCT04365764
SponsorGroupe Hospitalier Pitie-Salpetriere
Last Modified on9 April 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

admitted for severe Covid-19 pneumonia (i.e. requiring O2-support more than 6L/min with SpO2<96%)

Exclusion Criteria

patients who were previously in ICU
patients already hospitalized prior to study start date
patients in palliative care
lack of consent
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