RFR Change of Precise Segmental Versus Complete Renal Arterial Clamping During LPN for Clinical T1 RCC

  • STATUS
    Recruiting
  • End date
    Oct 24, 2021
  • participants needed
    100
  • sponsor
    Xuanwu Hospital, Beijing
Updated on 24 January 2021
carcinoma
nephrectomy

Summary

Renal functional reserve may be better in patients with clinical T1 renal cell carcinoma(RCC) undergoing laparoscopic partial nephrectomy with precise segmental renal artery clamping than those with complete renal arterial clamping.

Description

Renal functional reserve (RFR) describes the capacity of the intact nephron mass to increase glomerular filtration rate(GFR) from baseline in response to stimuli (e.g., protein load).We hypothesized that renal functional reserve may be better in patients with clinical T1 renal cell carcinoma(RCC) undergoing laparoscopic partial(LPN) nephrectomy with precise segmental renal artery clamping than those with complete renal arterial clamping.

Details
Condition Adenocarcinoma, Malignant neoplasm of kidney, Renal Cell Carcinoma, Kidney Cancer, Malignant Adenoma, Renal Cell Cancer, Renal Cancer, clear cell renal cell carcinoma
Treatment Laparoscopic partial nephrectomy, precise segmental renal arterial clamping
Clinical Study IdentifierNCT03259477
SponsorXuanwu Hospital, Beijing
Last Modified on24 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 18 yrs and 90 yrs?
Gender: Male or Female
Do you have any of these conditions: Renal Cell Cancer or Kidney Cancer or Malignant neoplasm of kidney or Malignant Adenoma or Renal Cancer or Adenocarcinoma or Renal Cell Carcinoma?
Do you have any of these conditions: Adenocarcinoma or Malignant neoplasm of kidney or Renal Cell Cancer or Renal Cancer or Malignant Adenoma or Renal Cell Carcinoma or Kidney Cancer or c...?
Age 18 2.Estimated GFR >30 mL/min/1.73m2 3.Anticipated intraoperative warm ischemic time 30 min 4.Subjects who signed informed consent forms

Exclusion Criteria

Allergy to iothalamate, shellfish or iodine
Use of metformin or amiodarone
intraoperative warm ischemic time >30 min
Inability to maintain a stable regimen of medications which affect GFR for > one week prior to participation (e.g. non-steroidal anti-inflammatory drugs, angiotensin converting enzyme inhibitors, angiotensin receptor blockers)
Use of medications which directly affect elimination of creatinine (e.g. cimetidine and trimethoprim)
Acute exacerbation of asthma or chronic obstructive pulmonary disease within 3 months requiring hospitalization or oral steroid therapy
Inadequate intravenous access
Severe anemia (Hct <21%)
Acute kidney injury (rise in creatinine to 1.5 times the previous baseline or by 0.3 mg/dL on most recent labs prior to enrollment)
History of contrast-induced nephropathy
Hyperthyroidism
Pheochromocytoma
Sickle cell disease
Urinary retention or incontinence
Status post organ transplant
Pregnancy or active breast feeding
Cognitive impairment with inability to give consent
Institutionalized status
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