Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial (CATCO)
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- STATUS
- Recruiting
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- End date
- May 18, 2024
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- participants needed
- 2900
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- sponsor
- Sunnybrook Health Sciences Centre
Summary
This study is an adaptive, randomized, open-label, controlled clinical trial, in collaboration with countries around the world through the World Health Organization.
Description
Subjects will be randomized, across one, two, three or up to four separate randomizations, to receive either standard-of-care products or the study medication plus standard of care, while being hospitalized for COVID-19.
Randomization WHO: Imatinib vs Infliximab vs Artesunate vs Standard of care
Randomization ARBs: ARBs vs Standard of care
Randomization Dex: Dexamethasone vs Standard of care
Randomization LSALT: LSALT Peptide vs Standard of care
Hospitalized subjects will require blood sampling for screening and on days 1 and 5. For participants randomized to Randomization 2 arm, research blood will be collected on baseline, Days 2, 4, 7 and 14, and in follow-up on 1, 3 and 6 month if hospitalized.
Details
| Condition | COVID-19 |
|---|---|
| Treatment | Lopinavir/Ritonavir, Dexamethasone, Infliximab, Imatinib, losartan, hydroxychloroquine, Interferon beta-1a, Artesunate, Remdesivir, LSALT peptide, ARBs |
| Clinical Study Identifier | NCT04330690 |
| Sponsor | Sunnybrook Health Sciences Centre |
| Last Modified on | 4 October 2022 |
How to participate?
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
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