Effect of Empagliflozin on Body Composition and Ketones

  • STATUS
    Recruiting
  • End date
    Dec 31, 2021
  • participants needed
    200
  • sponsor
    Seoul National University Bundang Hospital
Updated on 4 April 2021
type 2 diabetes mellitus
hypoglycemic agents
oral hypoglycemic

Summary

The purpose of this study is to evaluate changes of body composition induced by Sodium-glucose cotransporter-2 (SGLT2) inhibitor and its metabolic consequence in Korean type 2 diabetes (T2D).

Description

Sodium-glucose cotransporter-2 (SGLT2) inhibitor increases urinary excretion of glucose, promoting glycemic control and weight loss. However, it is unclear whether weight loss is attributed to decrease in fat components and associated with favorable changes in metabolic profile. The purpose of this study is to evaluate changes of body composition induced by SGLT2 inhibitor and its metabolic consequence in Korean type 2 diabetes (T2D).

Details
Condition Diabetes Mellitus, Diabetes Prevention, Diabetes Mellitus Types I and II, Diabetes (Pediatric), Fat; Intolerance, Pancreas, Fat; Intolerance, Pancreas, diabetes mellitus (dm), Fat; Intolerance, Pancreas, Fat; Intolerance, Pancreas, Fat; Intolerance, Pancreas
Treatment Empagliflozin 10 MG, Hypoglycemics Oral
Clinical Study IdentifierNCT03877406
SponsorSeoul National University Bundang Hospital
Last Modified on4 April 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 20 yrs?
Gender: Male or Female
Do you have any of these conditions: Diabetes Mellitus Types I and II or Diabetes Mellitus or Fat; Intolerance, Pancreas or Diabetes Prevention or Diabetes (Pediatric)?
Do you have any of these conditions: Diabetes (Pediatric) or Diabetes Mellitus Types I and II or Diabetes Prevention or Diabetes Mellitus or Fat; Intolerance, Pancreas or diabetes mellitu...?
Do you have any of these conditions: Diabetes Mellitus or Fat; Intolerance, Pancreas or Diabetes Mellitus Types I and II or Diabetes (Pediatric) or diabetes mellitus (dm) or Diabetes Prev...?
Do you have any of these conditions: diabetes mellitus (dm) or Diabetes Mellitus Types I and II or Diabetes (Pediatric) or Diabetes Prevention or Diabetes Mellitus or Fat; Intolerance, Pa...?
Patients with type 2 diabetes Age: 20-79 years BMI 20 kg/m2 eGFR 45

Exclusion Criteria

Patients with type 1 diabetes Secondary diabetes due to Cushing diseases
acromegaly Insulin user BMI < 20 kg/m2 eGFR < 45 Malignancy
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