PET/MRI Study on Changes of Fat and Muscle Metabolism.

  • STATUS
    Recruiting
  • End date
    Aug 1, 2023
  • participants needed
    300
  • sponsor
    Tang-Du Hospital
Updated on 3 March 2022
Accepts healthy volunteers

Summary

False positives for Brown Fat & MuscleF&M always affect the evaluation of metabolic disease treatment. Recently, using PET/CTinternational journals such as Journal of Nuclear Medicine reported that the amount of active brown fat was correlated with renal creatinine clearance and subject to regulation by atrial natriuretic peptide in addition to association of season and temperature. At presentstudies based on PET/CT have shown that elimination of the above factors, brown fat(even muscle) will still appear false positive metabolism in tumor patients. In view of the basis of Positron emission computed tomography/Magnetic resonance (PET/MRI) brain function researchour team speculate that it may be related to psychological or cortex metabolism. And there is a lack of studies on the correlation between the psychosocialcortex structure and metabolism. Therefore, it suggests thatcombination of structure and metabolismPET/MRI will play a role in studying the effects of psychological on F&M false-positive metabolism in malignant patients. In this project, the investigators intend to observe the changes of F&M metabolism with psychological and cortex metabolism after comprehensive treatment in malignant patient by combining PET/MRI. The relationship between F&M metabolism and psychological will be deeply analyzed to provide scientific basis for the development of the differential diagnosis and assessment.

Details
Condition Brown Fat and Muscle Metabolic, Differential Diagnosis
Treatment Comprehensive treatment of tumor
Clinical Study IdentifierNCT04334720
SponsorTang-Du Hospital
Last Modified on3 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Clinical diagnosis of malignant tumor
Have not yet been receiving comprehensive treatment and should begin within one month
Fasting glucose of diabetic patients is controlled below 11.1 mmol/L
Inclusion Criteria for Healthy Control Participants
Clinical diagnosis of Healthy Control

Exclusion Criteria

Fasting glucose 11.1mmol/L
History of endocrine disease (such as chronic glomerulonephritis, Addison's disease)
Neurological signs and/or history of neurological disease
Have begun comprehensive treatment
Presence of magnetically active objects in the body
Claustrophobia or any other medical condition that would preclude the participant from lying in the PET/MRI scanner for approximately 40 mins
Clear my responses

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