NordicTrip, a Translational Study of Preoperative Chemotherapy in TNBC
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- STATUS
- Recruiting
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- End date
- Dec 25, 2032
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- participants needed
- 820
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- sponsor
- Lund University Hospital
Summary
Primary aim: Pathological complete response rate after preoperative chemotherapy is the primary end-point of the study, which will be evaluated by comparing the effects of neoadjuvant administration of a carboplatin-based treatment and treatment adding capecitabine on Pathological Complete Response (pCR).
Description
Primary aim: Pathological complete response rate after preoperative chemotherapy is the primary end-point of the study, which will be evaluated by comparing the effects of neoadjuvant administration of a carboplatin-based treatment and treatment adding capecitabine on pCR.
Primary translational aim: To investigate if the effects of the treatments depend on homologous repair deficiency (HRD)-status. More specifically, the aim is to test for differential effect of the two treatments on pCR for HRD-negative (HRD low and intermediate by oncoscan) and HRD-positive (HRD high by oncoscan) patients.
Details
| Condition | Breast Cancer, Triple Negative Breast Neoplasms |
|---|---|
| Treatment | epirubicin, cyclophosphamide, paclitaxel, carboplatin, epirubicin, cyclophosphamide, capecitabine, paclitaxel, carboplatin |
| Clinical Study Identifier | NCT04335669 |
| Sponsor | Lund University Hospital |
| Last Modified on | 23 March 2022 |
Eligibility
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