The Impact of Watermelon Juice on Blood Pressure

  • days left to enroll
  • participants needed
  • sponsor
    University of Reading
Updated on 4 October 2022
Accepts healthy volunteers


L-citrulline is found naturally in watermelon. Recently interest has increased for this amino acid due to potential health benefits. Notably, L-citrulline has the potential to lead to dilation of blood vessels due to its involvement in the production of nitric oxide.

The study will be an acute single blind, randomised controlled, crossover intervention study in healthy, young volunteers. Participants receive either the test watermelon drink or control drink (water). Blood samples and vascular measures (by a single-cuff based method) will be measured at baseline. Vascular measures will be repeated at 15-minute intervals between 0-2 hours and a second blood sample will be drawn at 1.5 hours to coincide with the estimated peak plasma L-citrulline. Citrulline, arginine and nitric oxide metabolites will be measured in the blood samples.

Condition Healthy Aging
Treatment Water, Watermelon juice
Clinical Study IdentifierNCT04328311
SponsorUniversity of Reading
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Males and females
-30 years
Healthy (as per exclusion criteria)
Able to understand information sheet
Willing to comply with the study protocol
Able to give informed consent

Exclusion Criteria

Medical history of myocardial infarction
Medical history of angina
Medical history of thrombosis
Medical history of stroke
Medical history of cancer
Medical history of high cholesterol
Medical history of liver diseases
Medical history of renal diseases
Medical history of respiratory diseases
Medical history of bowel diseases
Medical history of diabetes
Medical history of other endocrine disorders
BMI <18.5 kg/m2 or >25 kg/m2
Blood pressure <90/60 or > 140/90 mmHg
Current use of antihypertensive medication
Pregnant or lactating
Alcohol intake > 14 units/week
Cigarette smoker (or quit within the last 6 months)
Vigorous exercise > 3 times/ week
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