Preservation of Blood in Extremely Preterm Infants

  • STATUS
    Recruiting
  • End date
    Jun 30, 2023
  • participants needed
    210
  • sponsor
    Lund University
Updated on 25 May 2021

Summary

Current clinical protocols for blood sampling and analyses in extremely preterm infants rely on an infrastructure adapted to and developed for adult medicine. Excessive blood sampling volumes and the resulting loss of fetal blood components are related to neonatal morbidity. This randomised trial aims to provide evidence that preservation of blood using micro-methods results in decreased morbidity and increased quality of life in extremely preterm infants.

Description

Extremely preterm (EPT) infants are subjected to a sample-related withdrawal of whole blood of 50 % of total blood volume during the first 2 postnatal weeks and a transfused volume of 100 % of total blood volume with donor blood during the corresponding time period. The resulting decrease in the proportion of fetal hemoglobin is strongly associated with morbidity outcome, especially broncho-pulmonary dysplasia (BPD), in the EPT infant.

This randomized trial evaluates if a reduction in sample-related blood volume loss by 50% during the first two postnatal weeks leads to a reduced rate of BPD in EPT infants. Half of the included infants will be subjected to clinical blood sampling using micromethods during the first two postnatal weeks whereas blood sampling in the other half of infants will be performed using standard clinical methods.

Details
Condition Bronchopulmonary Dysplasia, bronchopulmonary dysplasia (bpd)
Treatment Micromethods for blood sample analysis
Clinical Study IdentifierNCT04239690
SponsorLund University
Last Modified on25 May 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

gestational age < 27 weeks at birth

Exclusion Criteria

major malformation
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