Three-fourths of people diagnosed with gastric cancer will die from it. Researchers want to see if giving cancer drugs in a new way can help people live longer and delay the time it takes for the cancer to grow.
To find a better way to treat advanced stomach cancer.
People ages 18 and older with stomach cancer that has spread throughout their belly.
Participants will be screened with:
Blood, urine, and heart tests
Cancer sample: If they do not have one, they will have a biopsy.
Tests of performance of normal activities
Participants will have a laparoscopy. Small cuts are made into their abdomen. A thin camera with a light is inserted. Small instruments are used to take biopsies. This will be repeated during the study to monitor the cancer. During the first laparoscopy, a port with a catheter attached will be put into the abdomen.
Participants may also have an endoscopy: A thin tube with a camera is inserted through the mouth and into the stomach. The tube collects samples to monitor the cancer.
Participants will get paclitaxel every 3 weeks through the abdominal port and through a small plastic tube in an arm vein. They will also take capecitabine by mouth twice daily for the first 15 days of a 21-day cycle.
After participants finish 3 cycles, they will have scans to see how they are doing. They may get another course of therapy.
Participants will have visits every 3 weeks during treatment. Then they will have follow-up visits for 5 years. Then they will keep in touch with researchers for the rest of their life.
-Determine the progression free survival (PFS) in patients with peritoneal metastases from gastric cancer after repeated intraperitoneal chemotherapeutic infusion (IPC) and systemic paclitaxel administration with concomitant capecitabine therapy.
|Treatment||Capecitabine, Paclitaxel, BardPort Titanium Implanted Port withPeritoneal Catheter|
|Clinical Study Identifier||NCT04034251|
|Sponsor||National Cancer Institute (NCI)|
|Last Modified on||28 September 2020|
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