Effects of Oral Glucose and Teduglutide on Plasma Lipoproteins

  • STATUS
    Recruiting
  • End date
    May 5, 2022
  • participants needed
    15
  • sponsor
    University Health Network, Toronto
Updated on 5 May 2021
body mass index
gut hormone
glucagon
glp-2

Summary

Some of the fat (triglyceride) from the food humans eat gets stored in the bowel. This triglyceride can then be released into the blood when another meal is consumed or in response to hormones. How the gut hormone glucagon-like peptide-2 (GLP-2) and glucose release the triglyceride from the gut is not known. The research team in this study is interested in finding out how teduglutide (a degradation resistant form of GLP-2) ang glucose, given together, release stored triglyceride from the gut by evaluating how blood lipoproteins respond to teduglutide in healthy individuals.

Description

The lipoprotein response will be performed in 15 healthy individuals recruited by newspaper advertisements. A member of the study team will explain the study in detail on visit 1, and if the individual is interested in participating, informed consent will be obtained and preliminary screening will occur. On visit 2 participants will receive a high fat liquid meal after an overnight fast. Hourly blood samples will be taken for 5 hours, followed by a subcutaneous teduglutide injection and simultaneous glucose drink. Following the injection and drink, blood samples will be taken every 15 minutes for the first hour and every 30 minutes for the subsequent 3 hours.

Details
Condition Dyslipidemia, Hyperlipidemia, High Cholesterol (Hyperlipidemia), hyperlipidaemia
Treatment TED + glucose
Clinical Study IdentifierNCT03860688
SponsorUniversity Health Network, Toronto
Last Modified on5 May 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Men and women, aged 18 to 60 years
Body mass index 20 to 27 kg/m2

Exclusion Criteria

Patients with active inflammatory bowel disease
Patients with pre-existing Celiac disease, exocrine pancreatic insufficiency or small bowel malabsorption
Patients with active bowel malignancy
Patients with diabetes mellitus or known/ suspected motility disorders of the gut
Patients with decompensated liver disease
Patients on ezetimibe or bile acid sequestrants
Patients who are pregnant or breastfeeding
Patients with renal disease
Patients on benzodiazepine
Unstable cardiac or respiratory disease
Any changes to medication in the preceding month
Patients with hypersensitive to Revestive or any ingredient, active or a history of the drug within the last 5 years
Patients with GI malignancy (GI tract, hepatobiliary, pancreatic)
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