A Study to Assess a PI3Kδ Inhibitor (IOA-244) in Patients With Metastatic Cancers

  • End date
    Apr 3, 2024
  • participants needed
  • sponsor
Updated on 3 June 2022


The objective of study IOA-244-101 is to determine whether IOA-244 is safe and tolerable in cancer patients (Part A). In addition, the study will assess whether IOA-244 can increase the anti-tumour immune response in patients both as monotherapy and in combination pemetrexed/cisplatin/avelumab (Part B Mesothelioma and NSCLC 1st line), in combination with avelumab (Part B Cutaneous Melanoma and NSCLC 2nd/3rd line) and ruxolitinib (Part B Primary Myelofibrosis)

Condition Solid Tumor, Adult, Non-Hodgkin Lymphoma, Adult, NSCLC, Myelofibrosis, Uveal Melanoma
Treatment cisplatin, Ruxolitinib, Pemetrexed, IOA-244, Avelumab Injection
Clinical Study IdentifierNCT04328844
Last Modified on3 June 2022


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