Growth Hormone Adding to Controlled Ovarian Hyperstimulation for Improving Embryo Quality

  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    Reproductive & Genetic Hospital of CITIC-Xiangya
Updated on 23 March 2022


GH plays an important role in the synthesis of ovarian steroid hormone and follicular development as a paracrine hormone.GH can regulate the growth hormone receptor and strengthen the function of mitochondria to improve the quality of the female oocyte.In this study, a prospective randomized control was used to explore the effect of GH adjuvant therapy on embryo quality.

Condition Infertility,Female
Treatment Growth hormone
Clinical Study IdentifierNCT03966339
SponsorReproductive & Genetic Hospital of CITIC-Xiangya
Last Modified on23 March 2022


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Inclusion Criteria

)infertility women whose age ≥20 and ≤39 years old; 2)women has done IVF/ICSI assisted treatment ≥1 times; 3)number of IVF/ICSI assisted treatment cylces with ≥6 oocytes retrieved ≥1; 4)number of IVF/ICSI assisted treatment cylces with ≥50% fertilization rate ≥1 ; 5)historical assisted reproduction cycles without ≥6C-Ⅱ level embryos at the third day after oocytes retrieval or without blastocyst formation after blastocyst culturing

Exclusion Criteria

) Diseases related to IVF treatment outcome, such as untreated hydrosalpinx, uterine fibroids affecting uterine cavity, myometriosis, endometrial lesions, obvious uterine abnormalities,etc; 2)Severe acute or chronic liver or kidney diseases, such as cirrhosis, acute or chronic renal failure, hepatitis B virus activity period,etc.;in patients with abnormal liver and kidney function, the AST or ALT detection value was 2.5 times higher than the upper limit of normal, and the serum creatinine was 2 times higher than the upper limit of normal
)Endocrine and metabolic diseases and adrenal diseases, such as diabetes, Cushing's
syndrome,etc.; 4)People has allergy history of growth hormone product; 5)Participating in
other clinical research; 6)Other conditions that researchers determined not fit to be
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