Sleep Subtypes in Adolescent Depression

  • STATUS
    Recruiting
  • End date
    Jul 1, 2023
  • participants needed
    100
  • sponsor
    University of Bern
Updated on 29 May 2022
depression
insomnia
major depressive disorder
Accepts healthy volunteers

Summary

The purpose of this study is to compare sleep neurophysiology and behavior in adolescents with MDD with hypersomnia (MDD-HYP) and insomnia (MDD-INS) with healthy controls (HC). In addition, the investigators will test the efficacy of a simple behavioral sleep restriction on mood and sleep in their sample.

Description

The World Health Organization has identified depression as the leading cause of burden of disease amongst young people. Subjective sleep complaints are often a core symptom of depression and highly prevalent with 60-90% of depressed adolescents suffering from disrupted sleep. This sleep disruption often takes the form of insomnia (e.g., difficulty falling or staying asleep, or waking too early) or hypersomnia (prolonged sleep episodes or excessive daytime sleepiness). The aim of the trial is to examine the efficacy of a simple behavioral sleep restriction two weeks in duration on mood and sleep in adolescents ages 14 to 17 years with and without major depressive disorder. During this period sleep is objectively measured using actigraphy and monitor mood using self-report. The results of the study will inform whether a simple behavioral sleep restriction beneficially impacts mood and sleep.

Details
Condition Major Depressive Disorder
Treatment Behavioral Sleep Restriction
Clinical Study IdentifierNCT03742960
SponsorUniversity of Bern
Last Modified on29 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

This study will recruit adolescents (ages 14 to 17 years) with major depressive disorder (MDD) with insomnia (MDD-INS) and with hypersomnia (MDD-HYP) and age and gender matched controls (HC)
Inclusion Criteria
Key inclusion criteria for MDD Hypersomnia Group
MDD as determined through the MINI-KID
Determination of hypersomnia as defined by excessive daytime sleepiness, or long sleep duration
Written informed consent
Key inclusion criteria for MDD Insomnia Group
MDD as determined through the MINI-KID
Determination of insomnia as defined by the insomnia severity index
Written informed consent

Exclusion Criteria

Key exclusion criteria for all three groups include
Current or lifetime experience of frank psychosis or mania
Presence of suicidal intent representing imminent risk as indicated during clinical interview
Medical or neurological condition that could impact brain functioning
History of physical brain injury or blow to the head resulting in loss of consciousness greater than 5 minutes
Do not meet criteria for substance or alcohol dependence in the last three months
Presence of an organic sleep disorder (e.g., narcolepsy, sleep apnea)
Additional exclusion criteria for healthy control group
Presence of psychiatric disorder
Self-reported disrupted, short or ill-timed sleep
Additional exclusion criteria for MDD-INS and MDD-HYP
• No sleep difficulties
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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