NAD Therapy for Improving Memory and Brain Blood Flow in Older Adults With Mild Cognitive Impairment

  • End date
    Mar 31, 2023
  • participants needed
  • sponsor
    University of Delaware
Updated on 8 April 2021
mini-mental state examination
memory loss


This study will provide insight into whether a nutritional supplement, nicotinamide riboside (NR), improves memory and brain blood flow in older adults with low memory abilities. Overall, this project has the potential to identify a novel, safe and cost-effective strategy for decreasing age-related memory loss.

Condition Mild Cognitive Impairment, Mild Neurocognitive Disorder
Treatment Placebo, Niagen®
Clinical Study IdentifierNCT03482167
SponsorUniversity of Delaware
Last Modified on8 April 2021


Yes No Not Sure

Inclusion Criteria

Is your age between 60 yrs and 90 yrs?
Gender: Male or Female
Do you have Mild Cognitive Impairment?
Do you have any of these conditions: Mild Neurocognitive Disorder or Mild Cognitive Impairment?
Do you have any of these conditions: Mild Neurocognitive Disorder or Mild Cognitive Impairment?
Do you have any of these conditions: Mild Neurocognitive Disorder or Mild Cognitive Impairment?
Do you have any of these conditions: Mild Neurocognitive Disorder or Mild Cognitive Impairment?
Cognitive function scores consistent with amnestic mild cognitive impairment based on pre-screening evaluation
age 60-90 years
MMSE score >24 at time of initial consent

Exclusion Criteria

blood chemistries indicative of abnormal renal, liver, thyroid and adrenal function; estimated glomerular filtration rate using the MDRD prediction equation must be >30 ml/min/1.73 m2
any clinically significant abnormal blood chemistry values as determined by the research nurse or NMPCC nurse practitioner
major psychiatric disorder (e.g. schizophrenia, bipolar disorder, major depression within past two years)
neurological or autoimmune conditions affecting cognition (e.g. Parkinson's disease, epilepsy, multiple sclerosis, mild or severe traumatic brain injury, large vessel infarct)
concussion within last 2 years and 3 lifetime concussions
systemic medical illnesses (e.g. cardiovascular disease, cancer, renal failure)
substance abuse or dependence (DSM-V criteria)
current use of medications used to treat dementia (e.g., anticholinesterase drugs) or other drugs likely to affect cognition (e.g., anticholinergic drugs, long-acting benzodiazepines)
claustrophobia, metal implants, pacemaker or other factors affecting feasibility and/or safety of MRI scanning
current smoking (including marijuana) within the past 3 months
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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