The Impact of Vitamin C on Postoperative Acute Kidney Injury in Risk Patients Undergoing Valvular Heart Surgery

  • STATUS
    Recruiting
  • days left to enroll
    89
  • participants needed
    264
  • sponsor
    Yonsei University
Updated on 2 March 2022
sepsis
renal failure
vasopressor
acute renal failure
renal injury
heart surgery
shock
acute kidney injuries
vasoconstrictor

Summary

In cases of cardiac surgery or sepsis which cause inflammation, oxidative stress, endothelial injury and vasoplegia, serum vitamin C concentration is sharply decreased. The anti-inflammatory and anti-oxidant effects of vitamin C and the effects of reducing vasoconstrictor use have been demonstrated in patients with sepsis and septic shock, however, the foregoing effects have not been validated in patients undergoing cardiac surgery.

In this study, investigators investigate the effect of intravenous vitamin C on the incidence of acute renal injury after valvular heart surgery.

Details
Condition Acute Kidney Injury
Treatment Vitamin C, Control (Normal saline)
Clinical Study IdentifierNCT04210453
SponsorYonsei University
Last Modified on2 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients older than 20 years and undergoing elective valvular heart surgery whose preoperative acute renal failure score is 3 (moderate to severe risk)

Exclusion Criteria

Emergency operation
Cardiogenic shock or ventricular-assist device (eg. ECMO, IABP)
Severe chronic kidney disease (GFR(CKD-EPI) <30ml/min/1.73m2)
Patients with past history of gout or renal stone or hyperoxaluria or cystinuria
Hemolytic anemia due to pyruvate kinase deficiency or glucose-6-phosphate dehydrogenase deficiency
Sicklemia or thalassemia
Hemochromatosis
Allergy to disodium ethylenediamine-tetraacetate or ascorbic acid
Patients taking aspirin up to 3 days before surgery
Patients taking antiepileptic drug or fluphenazine or steroid
Patients taking vitamin C within a month of surgery
Pregnant or lactating women
Patients who cannot understand the informed consent (eg. Foreigner)
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