A Pharmacokinetic Interaction Study Between Apatinib Mesylate and Transporter Pgp Substrate Digoxin in Advanced Solid Tumor Subjects
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- STATUS
- Recruiting
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- End date
- Sep 12, 2021
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- participants needed
- 18
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- sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Summary
Apatinib, an oral inhibitor of vascular endothelial growth factor receptor 2VEGFR-2, Induces Transporter Pgp function in vitro. This study in patients with advanced cancer evaluated the effect of Apatinib on Transporter Pgp function by comparing the pharmacokinetics of Transporter Pgp-specific probe drugs in the presence and absence of Apatinib. The probes used Substrate Digoxin.
Details
| Condition | Advanced Solid Tumor, Advanced Malignant Solid Tumor |
|---|---|
| Treatment | Apatinib mesylate, Digoxin tablet |
| Clinical Study Identifier | NCT04322552 |
| Sponsor | Jiangsu HengRui Medicine Co., Ltd. |
| Last Modified on | 24 January 2021 |
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