A Pharmacokinetic Interaction Study Between Apatinib Mesylate and Transporter Pgp Substrate Digoxin in Advanced Solid Tumor Subjects

  • End date
    Sep 12, 2021
  • participants needed
  • sponsor
    Jiangsu HengRui Medicine Co., Ltd.
Updated on 24 January 2021
growth factor
advanced cancer
solid tumour


Apatinib, an oral inhibitor of vascular endothelial growth factor receptor 2VEGFR-2, Induces Transporter Pgp function in vitro. This study in patients with advanced cancer evaluated the effect of Apatinib on Transporter Pgp function by comparing the pharmacokinetics of Transporter Pgp-specific probe drugs in the presence and absence of Apatinib. The probes used Substrate Digoxin.

Condition Advanced Solid Tumor, Advanced Malignant Solid Tumor
Treatment Apatinib mesylate, Digoxin tablet
Clinical Study IdentifierNCT04322552
SponsorJiangsu HengRui Medicine Co., Ltd.
Last Modified on24 January 2021


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