Bariatric Surgery and Pharmacokinetics of Irbesartan

  • STATUS
    Recruiting
  • End date
    Oct 21, 2026
  • participants needed
    12
  • sponsor
    Norwegian University of Science and Technology
Updated on 21 April 2022
gastrectomy
bariatric surgery
gastric bypass
gastrointestinal transit
gastric ph

Summary

Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on irbesartan are investigated.

Details
Condition Obesity, Morbid
Treatment Irbesartan
Clinical Study IdentifierNCT03476603
SponsorNorwegian University of Science and Technology
Last Modified on21 April 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway
Being a Norwegian citizen

Exclusion Criteria

Having previously undergone resections in the GI-tract
Clear my responses

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