How TKA Implants Affect Muscle Quality and Activity During Daily Living and Immunological Response
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- STATUS
- Recruiting
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- End date
- Dec 19, 2023
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- participants needed
- 75
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- sponsor
- Ottawa Hospital Research Institute
Summary
This study compares two total knee replacement implants to asses muscle function and quality, and the immune response to the implants. 30 patients will receive the Smith and Nephew Journey II implant, while 30 patients will receive the Zimmer NexGen LPS-flex implant. 15 healthy controls will also be recruited and compared.
Description
Patients will undergo biomechanics testing while they complete sit-to-stand, stand-to-sit, lateral step down, level walking, and single leg balance tasks up to 1 month before surgery, and 6 and 12 months after surgery. They will also undergo MRI imaging up to 1 month before surgery and 12 months after surgery to assess muscle quality. A secondary outcome will also be to analyze the immunological response in the patients who received femoral components made of oxidized zirconium versus contemporary components made of cobalt chrome. Fifteen healthy controls will also participate in the study and will undergo the biomechanical, MRI and blood draws at a single visit.
Details
| Condition | Osteoarthritis, Knee, Inflammation Knees |
|---|---|
| Treatment | Zimmer NexGen LPS-Flex, Smith & Nephew Journey II |
| Clinical Study Identifier | NCT04105179 |
| Sponsor | Ottawa Hospital Research Institute |
| Last Modified on | 4 October 2022 |
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