Effect of Inferior Pulmonary Ligament Preservation in Patients With NSCLC Undergoing Thoracoscopic Upper Lobectomy

  • End date
    Dec 19, 2023
  • participants needed
  • sponsor
    Fujian Medical University Union Hospital
Updated on 2 March 2022


Many thoracic surgeons tend to dissect the inferior pulmonary ligament (IPL) during upper lobectomy, which in theory reduces the free space in the upper thoracic cavity by increasing the mobility of the residual lung. However, the dissection of IPL may lead to bronchial deformation, stenosis, obstruction or lobe torsion, distortion. Some studies have found that stenosis might be associated with chronic dry cough and shortness of breath, and could result in a significant decline in lung function. Moreover, the dissection of IPL may lead to greater surgical trauma and increase the incidence of complications. Therefore, this study tries to identify whether we should dissect or preserve the inferior pulmonary ligament during the thoracoscopic upper lobectomy.

Condition Lung Cancer, Nonsmall Cell
Treatment Dissection of the Inferior Pulmonary Ligament, Preservation of the Inferior Pulmonary Ligament
Clinical Study IdentifierNCT04120155
SponsorFujian Medical University Union Hospital
Last Modified on2 March 2022


Yes No Not Sure

Inclusion Criteria

Age and gender: 18-75 years old, male and female unlimited
Patients with NSCLC who are eligible for video-assisted upper left/upper right lobectomy
Participants volunteer to participate the study and signed the informed consent form
Preoperative pulmonary function test: FEV1> 1L and FEV1> 60% of predicted value
Preoperative ECOG:0-1
Preoperative ASA:I-II

Exclusion Criteria

Women in the the period of pregnancy or lactation
Patients suffering from any serious mental illness
Having the history of any thoracic surgery (only including intrathoracic surgery, excluding any superficial surgery like breast surgery, etc.)
Patients with unstable angina pectoris or myocardial infarction within half a year
Patients with cerebral infarction or cerebral hemorrhage within half a year
Received continuous systemic glucocorticoid therapy in the past 1 month
Abnormal coagulation function, bleeding tendency or receiving thrombolytic or antiplatelet treatment recently
Patients requiring emergency operation for severe lung cancer complication(bleeding/pneumothorax)
Patients with severe hepatic,renal insufficiency or other systematic dysfunction
Other conditions that are not suitable for the surgery
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