Developmental Epidemiological Study of Children Born Through Reproductive Technology (DESCRT)

  • End date
    Jul 1, 2024
  • participants needed
  • sponsor
    University of California, San Francisco
Updated on 2 March 2022
infertility treatment
reproductive technology
pregnancy early


DESCRT will be a long-term study that both looks back in time, at successful pregnancies, and forward in time at early pregnancy and long-term as these children grow. Currently, there are limited data on the long-term effects of infertility and infertility treatments on children. There are some studies to suggest that these children may have altered metabolic profiles, but this study aims to be the largest study to answer this question.


Over the past 30 years, much of the research and clinical effort in the field of ART had to do with improving outcome in terms of successful pregnancy. However, as these rates have increased, attention is slowly turning to focus on the health of the resultant child. Short-term health complications, in particular birth defects,have been well-described. However, even this "hard" outcome has been difficult to characterize as studies used different methodologies, varied age of detection, and frequently didn't have an appropriate comparison group. When underlying parental factors and infertility are included in the analyses, the association is substantially weakened or disappears completely. This exemplifies the problems with much of the currently available research regarding childhood outcomes following ART. While the health of children born through these technologies is of critical public health interest, and of personal interest to families, only limited data exist.

In order to evaluate the potential risk to long-term health of children conceived through assisted reproductive technologies (ART) and non-IVF fertility treatments (NIFT), rigorous epidemiological methods, appropriate characterization of the exposure, standardized collection of outcome data, and appropriate comparison groups are required. The proposed Developmental Epidemiological Study of Children born through Reproductive Technology (DESCRT) is aimed to carefully address these important characteristics.

Condition Infertility, Infertility, Female, Infertility, Male, Infertility Primary, Infertility Secondary, Infertility Unexplained
Clinical Study IdentifierNCT03799107
SponsorUniversity of California, San Francisco
Last Modified on2 March 2022


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Inclusion Criteria

seeking evaluation/treatment for infertility

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