Cardiac Output Assessment by Using Saline Contrast Injection

  • End date
    Mar 24, 2022
  • participants needed
  • sponsor
    Centre Hospitalier Universitaire, Amiens
Updated on 24 January 2021


Cardiac output (CO) assessment is one of the cornerstone of hemodynamic evaluation in ICU patients. CO is usually measured using invasive methods or non-invasive methods. Thermodilution is considered as the gold standard for CO assessment. Cardiac Doppler as well demonstrated to be accurate but needs manipulations and good knowledge and skills. The investigators developed a new technique using injection of agitated saline solution to evaluate CO without any manual measurement and then observer independent.


The investigators decided to conduct a prospective observational study to compare contrast assessment of CO and cardiac Doppler technique. Patients hospitalized in ICU will be included if they need a trans esophageal echocardiographic evaluation and a research of intra cardiac shunt (using a saline contrast test). Patients with Swan Ganz catheter will be included as well. Cardiac output will be measured using cardiac Doppler. Simultaneously, 4.5 ml of saline with 0.5 ml of air will be agitated to have a contrast solution. This solution will be injected as usual and echocardiographic imaging will be recorded. These imaging will be analyzed off-line and CO will be calculated with an algorithm previously developed and compared with the reference method. In case of swan ganz catheter, the cardiac output will be also measured using the thermodilution technique.

Condition Echocardiography, transthoracic echocardiography, sound measurement, heart ultrasound, echocardiograms
Treatment contrast assessment of cardiac output (CO), cardiac Doppler technique
Clinical Study IdentifierNCT04310904
SponsorCentre Hospitalier Universitaire, Amiens
Last Modified on24 January 2021


Yes No Not Sure

Inclusion Criteria

all ICU patients intubated/ventilated with a central line and an arterial catheter who need trans esophageal echocardiography examination with a saline contrast test

Exclusion Criteria

patients under 18 years old
pregnant patients
moribund patients
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