Last updated on June 2020

Evaluation of the Efficacy and Safety of Sarilumab in Hospitalized Patients With COVID-19


Brief description of study

Phase 2:

The primary objective of the study is to evaluate the clinical efficacy of sarilumab relative to the control arm in adult patients hospitalized with COVID-19 regardless of disease severity strata.

Phase 3 Cohort 1:

The primary objective of the study is to evaluate the clinical efficacy of sarilumab relative to the control arm in adult patients hospitalized with critical COVID-19 on mechanical ventilation at baseline.

Phase 3 Cohort 2:

The primary objective of the study is to evaluate the clinical efficacy of sarilumab relative to the control arm in adult patients hospitalized with COVID-19 receiving mechanical ventilation at baseline.

Phase 3 Cohort 3:

The primary objective of the study is to evaluate the clinical efficacy of sarilumab relative to the control arm in adult patients hospitalized with COVID-19 receiving high-intensity oxygen therapy* without mechanical ventilation at baseline.

  • High intensity oxygen therapy is defined as the use of non-rebreather mask with an oxygen flow rate of at least 10 L/min; use of a high flow device with at least 50% FiO2, or use of non-invasive ventilation (eg, BiPAP) or continuous positive airway pressure (CPAP) to treat hypoxemia.

Clinical Study Identifier: NCT04315298

Find a site near you

Start Over

Regeneron Study Site

New York, NY United States
  Connect »

Regeneron Study Site

Los Angeles, CA United States
  Connect »

Regeneron Study Site

Palo Alto, CA United States
  Connect »

Regeneron Study Site

Sacramento, CA United States
  Connect »

Regeneron Study Site

Santa Monica, CA United States
  Connect »

Regeneron Study Site

Aurora, CO United States
  Connect »

Regeneron Study Site

Denver, CO United States
  Connect »

Regeneron Study Site

New Haven, CT United States
  Connect »

Regeneron Study Site

Washington, WA United States
  Connect »

Regeneron Study Site

Coral Gables, FL United States
  Connect »

Regeneron Study Site

Gainesville, FL United States
  Connect »

Regeneron Study Site

Orlando, FL United States
  Connect »

Regeneron Study Site

Atlanta, GA United States
  Connect »

Regeneron Study Site

Decatur, GA United States
  Connect »

Regeneron Study Site

Marietta, GA United States
  Connect »

Regeneron Study Site

Chicago, IL United States
  Connect »

Regeneron Study Site

Baltimore, MD United States
  Connect »

Regeneron Study Site

Boston, MA United States
  Connect »

Regneron Study Site

Boston, MA United States
  Connect »

Regeneron Study Site

Ann Arbor, MI United States
  Connect »

Regeneron Study Site

Detroit, MI United States
  Connect »

Regeneron Study Site

Rochester, MN United States
  Connect »

Regeneron Study Site

Edison, NJ United States
  Connect »

Regeneron Study Site

Hackensack, NJ United States
  Connect »

Regeneron Study Site

Livingston, NJ United States
  Connect »

Regeneron Study Site

Morristown, NJ United States
  Connect »

Regeneron Study Site

Neptune, NJ United States
  Connect »

Regeneron Study Site

Newark, NJ United States
  Connect »

Regeneron Study Site

Teaneck, NJ United States
  Connect »

Regeneron Study Site

Bronx, NY United States
  Connect »

Regeneron Study Site 1

Bronx, NY United States
  Connect »

Regeneron Study Site 2

Bronx, NY United States
  Connect »

Regeneron Study Site

Brooklyn, NY United States
  Connect »

Regeneron Study Site

Elmhurst, NY United States
  Connect »

Regeneron Study Facility 2

Manhasset, NY United States
  Connect »

Regeneron Study Site 1

Manhasset, NY United States
  Connect »

Regeneron Study Site 1

New York, NY United States
  Connect »

Regeneron Study Site 2

New York, NY United States
  Connect »

Regeneron Study Site

Stony Brook, NY United States
  Connect »

Regeneron Study Site

Valhalla, NY United States
  Connect »

Regeneron Study Site

Portland, OR United States
  Connect »

Regeneron Study Site

Philadelphia, PA United States
  Connect »

Regeneron Study Site

Dallas, TX United States
  Connect »

Regeneron Study Site

Murray, UT United States
  Connect »

Regeneron Study Site

Falls Church, VA United States
  Connect »

Regeneron Study Site

Everett, WA United States
  Connect »

Regeneron Study Site

Renton, WA United States
  Connect »

Regeneron Study Site

New Orleans, LA United States
  Connect »

Regeneron Study Site

Tulsa, OK United States
  Connect »

Regeneron Study Site

Danville, PA United States
  Connect »

Regeneron Study Site

Scranton, PA United States
  Connect »

Regeneron Study Site

Wilkes-Barre, PA United States
  Connect »

Regeneron Study Site

Tampa, FL United States
  Connect »

Regeneron Study Site

Buffalo, NY United States
  Connect »

Regeneron Study Site 2

Manhasset, NY United States
  Connect »

Regeneron Study Site

Richmond, VA United States
  Connect »

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Volunteer Sign-up

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.