Comparing the Efficacy of Hybrid High-dose Dual and Bismuth Quadruple Therapies

  • STATUS
    Recruiting
  • End date
    Dec 31, 2021
  • participants needed
    918
  • sponsor
    Kaohsiung Veterans General Hospital.
Updated on 28 March 2021
clarithromycin
bismuth
peptic ulcer
gastritis

Summary

Both hybrid and high-dose dual therapies developed by the scholars from Taiwan can achieve a high eradication rate for clarithromycin-resistant strains, and have a great potential to replace bismuth quadruple therapy in the treatment of H. pylori infection.

Description

Bismuth quadruple therapy has been recommended as a choice of the first-line treatment for H. pylori infection in several important international consensuses. However, it is associated with a high frequency of adverse events. Both hybrid and high-dose dual therapies developed by the scholars from Taiwan can achieve a high eradication rate for clarithromycin-resistant strains, and have a great potential to replace bismuth quadruple therapy in the treatment of H. pylori infection. In the second-line treatment, tetracycline-levofloxacin quadruple therapy developed by our study group can achieve a higher eradication rate than levofloxacin triple therapy for salvage treatment of hybrid therapy. However, whether the new therapy can be a promising rescue treatment for bismuth quadruple or high-dose dual therapy remains unanswered.

Details
Condition Helicobacter Pylori Infection, H. Pylori Infection
Treatment 10d bismuth quadruple therapy, 14d hybrid therapy, 14D high-dose dual therapy
Clinical Study IdentifierNCT03779074
SponsorKaohsiung Veterans General Hospital.
Last Modified on28 March 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Consecutive H pylori-infected outpatients, at least 20 years of age, with endoscopically proven peptic ulcer diseases or gastritis

Exclusion Criteria

previous H pylori-eradication therapy
ingestion of antibiotics or bismuth within the prior 4 weeks
patients with allergic history to the medications used
patients with previous gastric surgery
the coexistence of serious concomitant illness (for example, decompensated liver cirrhosis, uremia)
pregnant women
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