68Ga-THP-PSMA PET/CT in Prostate Cancer: Clinical Stage and Restage

  • STATUS
    Recruiting
  • End date
    Dec 30, 2022
  • participants needed
    30
  • sponsor
    Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Updated on 27 January 2021
metastasis
pet/ct scan

Summary

To evaluate the dosimetry, safety and the detection rate of 68Ga-THP-PSMA PET/CT for identifying the site of prostate cancer metastasis and relapse. It is also to evaluate the association of clinical/pathologic features and 68Ga-THP-PSMA PET/CT detection rate and compare 68Ga-THP-PSMA PET/CT with other imaging procedure.

Details
Condition Malignant neoplasm of prostate, Prostatic disorder, Prostate Disorders, Prostate Cancer, Early, Recurrent, Prostate Cancer, prostate carcinoma, prostate cancers
Treatment 68Ga-Labeled PSMA, Non-labeled PSMA
Clinical Study IdentifierNCT04158817
SponsorShanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Last Modified on27 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult male, age 18 years or older
Prior diagnosis of prostatic cancer
Willing to participate in this study and given written informed consent
AST, ALT, BUN, Cr not more than double the normal values
Subjects of childbearing potential must be willing to undergo a pregnancy test prior to enrolment

Exclusion Criteria

Subjects with pacemakers
Hepatitis B virus infection (including carriers) at screening, i.e. hepatitis B surface antigen (HBsAg) positive, or hepatitis C antibody (anti-HCV) positive, or acquired immunodeficiency disease (HIV) infected, or serum syphilis positive person
Abnormal liver function during baseline screening period: AST or ALT> 2 times the upper limit of normal value (ULN), if the marginal increase of a single index is judged as having no clinical significance by the investigator, it can be retested during the screening period. Once, if more than 2 times ULN after retesting, consider enrolling)
Impaired renal function during screening: serum creatinine or urea nitrogen > 1.5 times ULN
Within 4 months prior to the baseline screening period, myocardial infarction or other cardiac events requiring hospitalization (unstable angina, etc.), cerebrovascular accident, transient ischemic attack, acute congestive Heart failure or severe arrhythmia (ventricular arrhythmia, atrioventricular block above II)
Subjects with pulmonary embolism or deep vein thrombosis
Various infections that the investigators consider unsuitable for study, including but not limited to patients with various infections requiring further treatment, such as urinary tract infections, respiratory infections, and diabetic foot infections
Patients with abnormal thyroid function during baseline screening period (including but not limited to active hyperthyroidism, hypothyroidism or Hashimoto's thyroiditis)
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