CADASIL Registry Study

  • End date
    Mar 9, 2049
  • participants needed
  • sponsor
    Bin Cai
Updated on 2 March 2022
Accepts healthy volunteers


The aim of this study is to determine the clinical spectrum and natural progression of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) and related disorders in a prospective multicenter study, to assess the clinical, genetic and epigenetic features of patients with CADASIL , to optimize clinical management.

Condition Cadasil
Clinical Study IdentifierNCT04310098
SponsorBin Cai
Last Modified on2 March 2022


Yes No Not Sure

Inclusion Criteria

Sign informed consent
Clinical diagnosis of patients with CADASIL,and confirmed by genetic test or skin biopsy
Asymptomatic NOTCH3 mutation carriers
Relatives of CADASIL patients or carriers
Unrelated healthy controls

Exclusion Criteria

Unable to cooperate with inspectors
Serious systemic illness, such as heart, liver, kidney disease or major mental illness
Contraindications for imaging examination
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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