Proximal Versus Distal Segments of No-Touch Saphenous Vein Grafts

  • days left to enroll
  • participants needed
  • sponsor
    China National Center for Cardiovascular Diseases
Updated on 23 January 2021


The optimum segment of No-Touch veins for bypassing is still undefined. The purpose of this study is to assess the incidence of leg wound complication after No-Touch harvesting of proximal segment of saphenous veins compared to distal segment of veins in the leg. Graft occlusion rates between the two segments of veins for bypassing will also be compared during follow-up.


This is a prospective, single-center, open-label, randomized within-subject-controlled trial. We aim to randomize 100 patients undergoing isolated coronary artery bypass graft (CABG). We consecutively screen patients during the study enrollment period and seek informed consent from all eligible patients. In each patient, one saphenous vein graft (SVG) will be randomized to be the proximal segment, while another will be the distal segment as control. Healing of leg wounds will be assessed on day 6 post-operatively. Follow-up will be performed via face-to-face interview until at least 1 year after the operation by CT angiography.

Condition Leg Wound Complication After No-Touch Harvestingof Veins, Leg Wound Complication After No-Touch Harvestingof Veins
Treatment Proximal and distal segment of saphenous vein harvested by No-Touch technique
Clinical Study IdentifierNCT04284956
SponsorChina National Center for Cardiovascular Diseases
Last Modified on23 January 2021


Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have Leg Wound Complication After No-Touch Harvestingof Veins?
Do you have any of these conditions: Do you have Leg Wound Complication After No-Touch Harvestingof Veins??
Patients aged 18 or older who undergo primary isolated open-chest CABG with two vein grafts, one to the left coronary territory and the other to the right, with or without cardiopulmonary bypass

Exclusion Criteria

Concomitant cardiac or vascular surgeries (i.e. valve repair or replacement, Maze surgery)
Emergent CABG (cardiogenic shock, inotropic pressure support, IABP)
Severe vein varicosity as assessed after vein harvesting and before randomization
Use of vascular stapler for anastomosis
Endarterectomy of coronary artery during surgery
Left ventricular repair due to ventricular aneurysm
Concomitant life-threatening disease likely to limit life expectancy to less than two years
Severe renal insufficiency (i.e. creatinine >200 mol/L)
Contraindications for dual antiplatelet therapy, such as active gastroduodenal ulcer
Participant of other ongoing clinical trials
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Phone Email

Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note