Hydroxychloroquine (HCQ) for Recurrent Pregnancy Loss

  • STATUS
    Recruiting
  • participants needed
    186
  • sponsor
    Rigshospitalet, Denmark
Updated on 1 February 2023
malaria
discoid lupus erythematosus

Summary

Recurrent pregnancy loss (RPL) defined as 3 or more pregnancy losses affects approximately 3% of couples trying to achieve parenthood. Most cases of RPL are unexplained and have no effective treatment to improve the chance of a live birth. Exciting indications for using Hydroxychloroquine (HCQ) include: Malaria profylaxis and treatment, systemic and discoid lupus erythematosus (SLE) and rheumatoid athritis (RA). HCQ has been reported to have the following properties (anti-thrombotic, vascular-protective, immunomodulatory, improving glucose tolerance, lipid-lowering, and anti-infectious).

There is no data concerning the benefit of HCQ in RPL. Administration for other indications provides extensive safety data during pregnancy.

This study has the potential to establish support for a new treatment option for unexplained RPL.

Details
Condition Recurrent Pregnancy Loss
Treatment hydroxychloroquine, Hydroxychloroquine Placebo
Clinical Study IdentifierNCT03305263
SponsorRigshospitalet, Denmark
Last Modified on1 February 2023

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