Vancomycin Dosage Strategy Based on a Trough Concentration Model

  • End date
    Dec 31, 2021
  • participants needed
  • sponsor
    Peking University Third Hospital
Updated on 23 January 2021


Study design:

Allocation: Randomized Endpoint classification: Efficacy study Masking: Open label Primary purpose: Treatment Primary endpoint: Incidence of reaching the target serum trough concentration Secondary endpoint: Clinical efficiency, Antibiotic use, acute kidney injury.


This is a prospective randomized control trial. There are two groups, study group and control group. Patients of study group accepted vancomycin strategies decided by a serum trough concentration model, and patients of control group accepted vancomycin dosage decided by attending physician. The primary endpoint is the incidence of reaching the target serum trough concentration, the secondary endpoint are clinical efficiency, antibiotic use and side effects such as acute kidney injury, etc.

Condition Staphylococcal Pneumonia
Treatment Dose
Clinical Study IdentifierNCT04088305
SponsorPeking University Third Hospital
Last Modified on23 January 2021


Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 60 yrs?
Gender: Male or Female
Do you have Staphylococcal Pneumonia?
Do you have any of these conditions: Do you have Staphylococcal Pneumonia??
Patients with doubted or diagnosed Methicillin-resistant Staphylococcus aureus severe pneumonia, and need vancomycin treatment
Sixty years and older

Exclusion Criteria

younger than 60 years old
Accepted blood purification therapy
Positive HIV antibody titre
Had known or suspected tuberculosis or other infections caused by fungi at baseline
Clear my responses

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