A Study of TAS-120 in Patients With Metastatic Breast Cancer

  • End date
    Dec 15, 2021
  • participants needed
  • sponsor
    Taiho Oncology, Inc.
Updated on 25 January 2021
platelet count
measurable disease
breast cancer
endocrine therapy
neutrophil count
hormone therapy
liver metastasis
cancer chemotherapy
progesterone receptor
estrogen receptor
her2-negative breast cancer


The purpose of this open-label, nonrandomized, Phase 2 study is to evaluate the efficacy and safety of TAS-120 and TAS-120 + fulvestrant in patients with locally advanced/metastatic breast cancer harboring FGFR gene amplifications.


Up to approximately 168 patients will be enrolled among the 4 cohorts as outlined below:

  • Cohort 1 - HR+ HER2- Measurable Disease w/ FGFR2 Amplification
  • Cohort 2 - TNBC Measurable Disease w/ FGFR2 Amplification
  • Cohort 3 - HR+ HER2- or TNBC Non-Measurable Disease w/ FGFR2 Amplification
  • Cohort 4 - HR+ HER2- Measurable Disease w/ FGFR1 Amplification

Condition Metastatic Breast Cancer, Stage IV Breast Cancer, FGFR2 Amplification
Treatment fulvestrant, TAS-120
Clinical Study IdentifierNCT04024436
SponsorTaiho Oncology, Inc.
Last Modified on25 January 2021


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