Determination of Blood Tumor Cells

  • End date
    Mar 30, 2023
  • participants needed
  • sponsor
    University of Zurich
Updated on 17 October 2021
hematologic malignancy


Magnetic nanoparticles coated with anti-EpCAM or anti-CD52 antibodies will be tested ex-vivo in patients blood .


Magnetic nanoparticles, coated with epithelial cell adhesion molecule (EpCAM)-antibodies are designed to interact with epithelial tumor cells. Aim of this study is to see if circulating tumor cells (EpCAM as marker)can be removed out of the blood with the help of these particles. Patients suffering from prostate, colon, lung or pancreatic cancer will be asked to test their blood.

Similarly, magnetic nanoparticles will be coated with antibodies, directed against non-solid tumors in the blood such as lymphoma or leukemia (CD52 as marker).

Condition Chronic Lymphocytic Leukemia, Lymphocytic Leukemia, Chronic, Abnormalities Cell Epithelial
Clinical Study IdentifierNCT04290923
SponsorUniversity of Zurich
Last Modified on17 October 2021


Yes No Not Sure

Inclusion Criteria

Epithelial cell cancer, advanced stage Non-solid tumors (lymphoma, leukemia)

Exclusion Criteria

Inability to understand the language of the center (German)
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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