Last updated on December 2009

Predictors of Cognitive Decline in Normal Aging

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Alzheimer Disease | Dementia
  • Age: Between 60 - 80 Years
  • Gender: Male or Female
  • Other:
    Males and females, from all racial and ethnic categories between the ages of 60-80
    years of age, with English as their first language.
    Residents of the New York City metropolitan area.
    Minimum of 12 years of education.
    Participants will be grouped according to the following classifications: normal
    aging, mild cognitive impairment (MCI), Alzheimer's disease (AD), or frontotemporal
    dementia (FTD).
    Participants will agree to ApoE genotyping and DNA banking.

You may not be eligible for this study if the following are true:

  • Past history or MRI evidence of brain damage including significant trauma, stroke,
    hydrocephalus, lacunar infarcts, seizures, mental retardation or serious neurological
    Significant history of alcoholism or drug abuse.
    History of psychiatric illness (e.g., schizophrenia, mania or depression).
    Any focal signs or significant neuropathology.
    A score of 4 or greater on the Modified Hachinski Ischemia Scale suggesting
    cerebrovascular disease.
    A total score of 16 or more on the Hamilton Depression Scale to exclude possible
    cases of primary depression.
    Evidence of clinically relevant and uncontrolled hypertensive, cardiac, pulmonary,
    vascular, metabolic or hematologic conditions.
    Physical impairment of such severity as to adversely affect the validity of
    psychological testing.
    Hostility or refusal to cooperate.
    Any prosthetic devices (e.g., pacemaker or surgical clips) that could be affected by
    the magnetic field employed during MRI imaging.
    History of familial early onset dementia.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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