Preventing Levodopa Induced Dyskinesia in Parkinson's Disease With HMG-CoA Reductase Inhibitors

  • End date
    Mar 31, 2024
  • participants needed
  • sponsor
    VA Office of Research and Development
Updated on 1 March 2021


In this study, the investigators will examine the association of statin use and dyskinesia in a convenience sample Parkinson's disease patients in the Veterans Administration Health Care System.


Long term treatment with levodopa, the gold standard treatment of Parkinson's disease (PD), can lead to the development of abnormal involuntary movements called levodopa induced dyskinesia (LID). The severity of LID can range from mild to severely debilitating. A majority of PD patients will develop LID in their treatment life-time. In a recent study of the MPTP monkey model of PD, statin use was found to reduce LID (45%) without a worsening of Parkinsonism symptoms1. Another study showed rats treated with lovastatin prior to and with initiation of levodopa after substantia nigra lesioning showed dramatically less LID evolution compared to animals without lovastatin exposure2. In this study, the investigators will examine the association of statin use and dyskinesia in a convenience sample Parkinson's disease patients in the Veterans Administration Health Care System. This study is a retrospective three cohort design and will compare statin exposure BEFORE beginning LD, versus statin exposure AFTER LD is begun, versus NO statin exposure in PD subjects controlling for disease characteristics (severity), gender, and total LD exposure The primary endpoint is the severity of LID between the groups after years of opportunity to develop LID. Levodopa-Induced dyskinesia is a major cause of reduced quality of life for Veterans with PD and, in some cases, leads to costly surgical interventions. This project examines the impact of statin use on the presence of LID, and could lead to a future intervention trial. The reduction, delayed onset, or elimination of LID could improve the quality of life of many Veterans nationwide.

Condition Drug-induced dyskinesia, Parkinson's disease, parkinson's, parkinson disease
Treatment Intravenous Infusion
Clinical Study IdentifierNCT04064294
SponsorVA Office of Research and Development
Last Modified on1 March 2021


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Inclusion Criteria

Is your age greater than or equal to 50 yrs?
Gender: Male or Female
Do you have any of these conditions: Parkinson's disease or Drug-induced dyskinesia?
Do you have any of these conditions: Drug-induced dyskinesia or parkinson's or Parkinson's disease or parkinson disease?
Do you have any of these conditions: Parkinson's disease or Drug-induced dyskinesia or parkinson disease or parkinson's?
Parkinson's Disease
Age diagnosed with Parkinson's Disease greater than or equal to 50 years
Treatment with levodopa greater than or equal to 5 years

Exclusion Criteria

Deep Brain stimulation
Unable to stand for 1 minute intervals, or sensory deficits in the feet
Significant cognitive impairment as measured by the Montreal Cognitive Assessment score of < 18
Subjects with unstable medical or psychiatric conditions (including hallucinations)
History of unstable medical conditions (i.e. active cardiac disease, recent unwellness, surgery etc.)
Current use of drugs that may affect parkinsonism or dyskinesia
dopamine receptor blocking medications
and illicit drugs such as marijuana (THC)
Statins other than simvastatin or lovastatin ie atorvastatin, fluvastatin
rationale is that while all other statins are thought to not cross the blood brain barrier well, the central nervous system penetrating nature of others is not perfectly clear and could confound results
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